Development of Scaffold Synthesis for the Preparation of New Insulin-Like Growth Factor 1 Receptor Inhibitors

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• 作者：Ilaria Candiani ; Germano D’ ; Arasmo ; Franco Heidempergher ; Attilio Tomasi
• 刊名：Organic Process Research & Development
• 出版年：2009
• 出版时间：May 15, 2009
• 年：2009
• 卷：13
• 期：3
• 页码：456-462
• 全文大小：147K
• 年卷期：v.13,no.3(May 15, 2009)
• ISSN：1520-586X

文摘

The synthesis of new insulin-like growth factor 1 receptor (IGF-1R) inhibitors is reported. The described molecules have a new sulfonyl-indazole structure. We describe the process research and development for the scaffold synthetic procedure in order to provide the large amount of product required for lead optimization, candidate selection, and preclinical studies.