Sesterterpenoids Isolated from a Northeastern Pacific Phorbas sp.
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- 作者：Julie Daoust ; Min Chen ; Meng Wang ; David E. Williams ; Miguel Angel Garcia Chavez ; Yan Alexander Wang ; Catherine E. Merchant ; Angelo Fontana ; Timothy J. Kieffer ; Raymond J. Andersen
- 刊名：Journal of Organic Chemistry
- 出版年：2013
- 出版时间：September 6, 2013
- 年：2013
- 卷：78
- 期：17
- 页码：8267-8273
- 全文大小：399K
- 年卷期：v.78,no.17(September 6, 2013)
- ISSN：1520-6904
文摘
Four new sesterterpenoids, ansellone B (4), phorbadione (5), secoepoxyansellone A (6), and alotaketal C (7), have been isolated from specimens of the sponge Phorbas sp. collected in British Columbia. Ansellone B (4) has an unprecedented heterocyclic skeleton featuring an oxocane ring, and secoepoxyansellone A (6) is the first example of the degraded 鈥渟ecoansellane鈥?sesterterpenoid carbon skeleton. Alotaketal C (7) is an activator of cAMP signaling in HEK cells.