Catalytic Enantioselective Desymmetrization of meso-Diamines: A Dual Small-Molecule Catalysis Approach

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• 作者：Chandra Kanta De ; Daniel Seidel
• 刊名：Journal of the American Chemical Society
• 出版年：2011
• 出版时间：September 21, 2011
• 年：2011
• 卷：133
• 期：37
• 页码：14538-14541
• 全文大小：814K
• 年卷期：v.133,no.37(September 21, 2011)
• ISSN：1520-5126

文摘

The desymmetrization of meso-diamines was accomplished via enantioselective monobenzoylation facilitated by the cooperative action of two small-molecule catalysts. A chiral acyl-transfer reagent is formed in situ through the interplay of benzoic anhydride, 4-(dimethylamino)pyridine as a nucleophilic catalyst, and a chiral amide鈥搕hiourea cocatalyst.