Bioactive Polybrominated Diphenyl Ethers from the Marine Sponge Dysidea sp.
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- 作者：Hui Zhang ; Andrew Skildum ; Emily Stromquist ; Teresa Rose-Hellekant ; Leng Chee Chang
- 刊名：Journal of Natural Products
- 出版年：2008
- 出版时间：February 2008
- 年：2008
- 卷：71
- 期：2
- 页码：262 - 264
- 全文大小：180K
- 年卷期：v.71,no.2(February 2008)
- ISSN：1520-6025
文摘
A new polybrominated diphenyl ether (9), together with eight known compounds, were isolated from the crude organic extract of the marine sponge Dysidea sp. collected from the Federated States of Micronesia. Their structures were elucidated on the basis of various NMR spectroscopic data. These compounds exhibited inhibitory activities against Streptomyces 85E in the hyphae formation inhibition (HFI) assay and displayed antiproliferative activities against the human breast adenocarcinoma cancer cell line MCF-7. Compound 6 was selected for further evaluation in a cell cycle progression study.