Antiproliferative and Chemopreventive Effects of Adlay Seed on Lung Cancer in Vitro and in Vivo

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• 作者：Hui-Chiu Chang ; Yu-Chun Huang ; and Wen-Chun Hung
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2003
• 出版时间：June 4, 2003
• 年：2003
• 卷：51
• 期：12
• 页码：3656 - 3660
• 全文大小：80K
• 年卷期：v.51,no.12(June 4, 2003)
• ISSN：1520-5118

文摘

This study examined the effects of different extracts of adlay seed on the growth of human lungcancer cells in vitro and in vivo. The data showed that a methanolic extract, but not a water extract,of adlay seed exerted an antiproliferative effect on A549 lung cancer cells by inducing cell cyclearrest and apoptosis. It was also found that tumor growth in vivo was inhibited by the methanolicextract in a dose-dependent manner. The chemopreventive effect of adlay seed on the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesisin A/J mice was also investigated. Groups of mice were pre-fed with different diets, followed by feedingwith NNK-containing drinking water for 8 months. The results indicated that feeding with diet containing30% of powdered adlay seed reduced the number of surface lung tumors by ~50%. Taken together,these results indicate that the components of adlay seed exert an anticancer effect in vitro and invivo and may be useful for the prevention of lung tumorigenesis.Keywords: Adlay seed; chemoprevention; lung tumorigenesis; NNK; apoptosis