Norterpenoids and Related Peroxides from the Formosan Marine Sponge Negombata corticata

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• 作者：Chih-Hua Chao ; Kuei-Ju Chou ; Guey-Horng Wang ; Yang-Chang Wu ; Li-Hsueh Wang ; Jeng-Ping Chen ; Jyh-Horng Sheu ; Ping-Jyun Sung
• 刊名：Journal of Natural Products
• 出版年：2010
• 出版时间：September 24, 2010
• 年：2010
• 卷：73
• 期：9
• 页码：1538-1543
• 全文大小：186K
• 年卷期：v.73,no.9(September 24, 2010)
• ISSN：1520-6025

文摘

Six norterpenes including negombatoperoxides A and B (4 and 5), the inseparable epimers negombatoperoxides C and D (6 and 7), negombatodiol (8), and negombatolactone (9), in combination with three known compounds, (+)-nuapapuin B (1), (+)-nuapapuin B methyl ester (2), and (+)-aikupikoxide C (3), were isolated from the Formosan marine sponge Negombata corticata. In addition, 6,6-dimethylundecane-2,5,10-trione (10) was isolated for the first time from a natural source. Their structures, including relative configurations, were elucidated on the basis of interpretation of spectroscopic data and by the application of the empirical rule established by Capon and MacLeod. The absolute configurations of 8 and 9 were established by the application of Mosher’s method and comparison of CD data with known lactones, respectively. Cytotoxicity of these isolates against human breast carcinoma, human liver carcinoma, and human lung carcinoma cell lines was evaluated.