Shape Transformation of Light-Responsive Pyrene-Containing Micelles and Their Influence on Cytoviability

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• 作者：Haisheng Wang ; Wenbo Zhang ; Changyou Gao
• 刊名：Biomacromolecules
• 出版年：2015
• 出版时间：August 10, 2015
• 年：2015
• 卷：16
• 期：8
• 页码：2276-2281
• 全文大小：344K
• ISSN：1526-4602

文摘

The amphiphilic pyrene-containing random copolymers with light-responsive pyrene ester bonds were synthesized by copolymerizing 1-pyrenemethyl acrylate (PA) and N,N-dimethylacrylamide (DMA). The P(DMA-co-PA) copolymers formed spherical micelles in water, which were transformed into nanorods as a result of cleavage of the pyrene ester bonds under UV irradiation. In vitro culture with A549 cells and Raw cells showed that compared to the nonphotodegradable ones, the photodegradable P(DMA-co-PA) micelles caused significantly higher cytotoxicity under the same UV irradiation. The intracellular reactive oxygen species (ROS) level had a positive correlation with the cytotoxicity regardless of the cell types. The nonphotodegradable pyrene-containing micelles produced a lower level of ROS under UV irradiation. However, the photodecomposable P(DMA-co-PA) micelles produced a significant higher level of ROS under the same trigger of UV irradiation, which caused the shape transformation of micelles to nanorods and higher cytotoxicity simultaneously.