Structurally Defined Nanoscale Sheets from Self-Assembly of Collagen-Mimetic Peptides

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• 作者：Tao Jiang ; Chunfu Xu ; Yang Liu ; Zheng Liu ; Joseph S. Wall ; Xiaobing Zuo ; Tianquan Lian ; Khalid Salaita ; Chaoying Ni ; Darrin Pochan ; Vincent P. Conticello
• 刊名：Journal of the American Chemical Society
• 出版年：2014
• 出版时间：March 19, 2014
• 年：2014
• 卷：136
• 期：11
• 页码：4300-4308
• 全文大小：410K
• 年卷期：v.136,no.11(March 19, 2014)
• ISSN：1520-5126

文摘

We report the design of two collagen-mimetic peptide sequences, NSI and NSII, that self-assemble into structurally defined nanoscale sheets. The underlying structure of these nanosheets can be understood in terms of the layered packing of collagen triple helices in two dimensions. These nanosheet assemblies represent a novel morphology for collagen-based materials, which, on the basis of their defined structure, may be envisioned as potentially biocompatible platforms for controlled presentation of chemical functionality at the nanoscale. The molecularly programmed self-assembly of peptides NSI and NSII into nanosheets suggests that sequence-specific macromolecules offer significant promise as design elements for two-dimensional (2D) assemblies. This investigation provides a design rubric for fabrication of structurally defined, peptide-based nanosheets using the principles of solution-based self-assembly facilitated through complementary electrostatic interactions.