Asymmetric [3 + 2] Cycloaddition of Methyleneindolinones with N,N鈥?Cyclic Azomethine Imines Catalyzed by a N,N鈥?Dioxide鈥揗g(OTf)2 Complex
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- 作者：Chengkai Yin ; Lili Lin ; Dong Zhang ; Juhua Feng ; Xiaohua Liu ; Xiaoming Feng
- 刊名：Journal of Organic Chemistry
- 出版年：2015
- 出版时间：October 2, 2015
- 年：2015
- 卷：80
- 期：19
- 页码：9691-9699
- 全文大小：529K
- ISSN：1520-6904
文摘
A highly efficient chiral N,N鈥?dioxide鈥揗g(OTf)2 catalyst system has been developed for the asymmetric 1,3-dipolar cycloaddition between methyleneindolinones and N,N鈥?cyclic azomethine imines. The desired pyrazolidine products with contiguous quaternary鈥搕ertiary stereocenters were obtained in up to 99% yields with up to 99% ee and >19:1 dr under mild reaction conditions.