Synthesis of Tetrahydropyridine Derivatives through a Modular Assembly Reaction Using 3,4-Dihydropyran as Dual Substrate and Template

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• 作者：Shaohuan Sun ; Cheng Cheng ; Jian Yang ; Amir Taheri ; Dan Jiang ; Biao Zhang ; Yanlong Gu
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：September 5, 2014
• 年：2014
• 卷：16
• 期：17
• 页码：4520-4523
• 全文大小：340K
• ISSN：1523-7052

文摘

A concise method to synthesize 1,2,3,4-tetrahydropyridines is described that involves the use of 2-alkoxy-3,4-dihydropyran as a modular precursor to react with aniline and a nucleophile. In this method, the heteroatom of the dihydropyran ring was replaced by nitrogen of aniline while the nucleophile attached to its adjacent position. Various druglike polyheterocycles were prepared with this method by using NH₂-containing 1,5- or 1,4-bisnucleophiles.