Ligand-Enabled Stereoselective 尾-C(sp3)鈥揌 Fluorination: Synthesis of Unnatural Enantiopure anti-尾-Fluoro-伪-amino Acids
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- 作者：Ru-Yi Zhu ; Keita Tanaka ; Gen-Cheng Li ; Jian He ; Hai-Yan Fu ; Su-Hua Li ; Jin-Quan Yu
- 刊名：Journal of the American Chemical Society
- 出版年：2015
- 出版时间：June 10, 2015
- 年：2015
- 卷：137
- 期：22
- 页码：7067-7070
- 全文大小：314K
- ISSN：1520-5126
文摘
A quinoline-based ligand was shown to promote palladium-catalyzed 尾-C(sp3)鈥揌 fluorination for the first time. A range of unnatural enantiopure fluorinated 伪-amino acids were obtained through sequential 尾-C(sp3)鈥揌 arylation and subsequent stereoselective fluorination from readily available l-alanine.