Indiosides G鈥揔: Steroidal Glycosides with Cytotoxic and Anti-inflammatory Activities from Solanum violaceum

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• 作者：Chiao-Ting Yen ; Chia-Lin Lee ; Fang-Rong Chang ; Tsong-Long Hwang ; Hsin-Fu Yen ; Chao-Jung Chen ; Shu-Li Chen ; Yang-Chang Wu
• 刊名：Journal of Natural Products
• 出版年：2012
• 出版时间：April 27, 2012
• 年：2012
• 卷：75
• 期：4
• 页码：636-643
• 全文大小：327K
• 年卷期：v.75,no.4(April 27, 2012)
• ISSN：1520-6025

文摘

Five new steroidal glycosides (1鈥?b>5) and nine known compounds were isolated from Solanum violaceum. Indiosides G (1) and H (2) are spirostene saponins with an iso-type F ring, indioside I (3) is a spirostane saponin, and indiosides J (4) and K (5) are unusual furostanol saponins with a deformed F ring. These structures represent rare naturally occurring steroidal skeletons. The structures of the new compounds were elucidated using 1D and 2D spectroscopic techniques and acid hydrolysis. Compounds 2, 3, and 7鈥?b>9 exhibited cytotoxic activity against six human cancer cell lines (HepG2, Hep3B, A549, Ca9-22, MDA-MB-231, and MCF-7) with IC₅₀ values of 1.83鈥?.04 渭g/mL. Steroidal saponins 3, 8, and 9 showed inhibitory effects on superoxide anion generation with IC₅₀ values of 2.84 卤 0.18, 0.62 卤 0.03, and 1.62 卤 0.59 渭g/mL, respectively. Saponins 8 and 9 also inhibited elastase release with IC₅₀ values of 111.05 卤 7.37 and 4.04 卤 0.51 渭g/mL, respectively. Structure鈥揳ctivity relationship correlations of these compounds with respect to cytotoxic and anti-inflammatory effects are discussed.