Bioactive Diterpenes from Callicarpa longissima

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• 作者：Yuan-Wei Liu ; Yuan-Bin Cheng ; Chia-Ching Liaw ; Chung-Hsiung Chen ; Jih-Hwa Guh ; Tsong-Long Hwang ; Ji-Shu Tsai ; Won-Bo Wang ; Ya-Ching Shen
• 刊名：Journal of Natural Products
• 出版年：2012
• 出版时间：April 27, 2012
• 年：2012
• 卷：75
• 期：4
• 页码：689-693
• 全文大小：291K
• 年卷期：v.75,no.4(April 27, 2012)
• ISSN：1520-6025

文摘

Investigation of the leaves and twigs of Callicarpa longissima resulted in the isolation of four new compounds (1鈥?b>4), callilongisins A鈥揇, and five known compounds, ursolic acid, 3-oxoanticopalic acid, (E)-6尾-hydroxylabda-8(17),13-dien-15-oic acid, 5-hydroxy-3,6,7,4鈥?tetramethoxyflavone, and artemetin. Compounds 1鈥?b>3 are 3,4-seco-abietane-type diterpenoids, and compound 4 is an analogue of a labdenoic-type diterpene. The structure of compound 1 was confirmed by X-ray crystallographic analysis. Cytotoxicity against a human prostate cancer cell line (PC3) and anti-inflammatory activities of the isolated compounds were evaluated.