Anti-inflammatory Cembranoids from the Soft Corals Sinularia querciformis and Sinularia granosa

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• 作者：Yi Lu ; Chiung-Yao Huang ; Yu-Fang Lin ; Zhi-Hong Wen ; Jui-Hsin Su ; Yao-Haur Kuo ; Michael Y. Chiang ; Jyh-Horng Sheu
• 刊名：Journal of Natural Products
• 出版年：2008
• 出版时间：October 24, 2008
• 年：2008
• 卷：71
• 期：10
• 页码：1754-1759
• 全文大小：237K
• 年卷期：v.71,no.10(October 24, 2008)
• ISSN：1520-6025

文摘

Four new cembranoids, querciformolides A−D (1−4), along with two known cembranoids, 7 and 8, have been isolated from the soft coral Sinularia querciformis. Furthermore, chemical investigation of Sinularia granosa has afforded three new cembranoids, querciformolide B (2) and granosolides A (5) and B (6). The structures of the new metabolites were elucidated on the basis of extensive spectroscopic methods, and that of 2 was further confirmed by X-ray diffraction analysis. The absolute configurations of 1 and 2 were determined by a modified Mosher’s method. Among these metabolites, 2−6 are rarely found cembranoids possessing a tetrahydrofuran moiety with a 4,7-ether linkage; in addition, 1 is the first ε-lactone cembrane found that possesses a tetrahydropyran moiety with a 4,8-ether linkage. None of these compounds were found to be cytotoxic toward a limited panel of cancer cell lines. However, compounds 3, 7, and 8 significantly inhibited the accumulation of the pro-inflammatory iNOS and COX-2 proteins in LPS-stimulated RAW264.7 macrophage cells.