A Mononuclear Manganese(II) Complex Demonstrates a Strategy To Simultaneously Image and Treat Oxidative Stress
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- 作者：Meng Yu ; Stephen L. Ambrose ; Zachary L. Whaley ; Sanjun Fan ; John D. Gorden ; Ronald J. Beyers ; Dean D. Schwartz ; Christian R. Goldsmith
- 刊名：Journal of the American Chemical Society
- 出版年：2014
- 出版时间：September 17, 2014
- 年：2014
- 卷：136
- 期：37
- 页码：12836-12839
- 全文大小：252K
- ISSN：1520-5126
文摘
A manganese(II) complex with a ligand containing an oxidizable quinol group serves as a turn-on sensor for H2O2. Upon oxidation, the relaxivity of the complex in buffered water increases by 0.8 mM鈥? s鈥?, providing a signal that can be detected and quantified by magnetic resonance imaging. The complex also serves as a potent antioxidant, suggesting that this and related complexes have the potential to concurrently visualize and alleviate oxidative stress.