Solid Phase Synthesis of C-Terminal Boronic Acid Peptides

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• 作者：Mira A. M. Behnam ; Tom R. Sundermann ; Christian D. Klein
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：May 6, 2016
• 年：2016
• 卷：18
• 期：9
• 页码：2016-2019
• 全文大小：286K
• 年卷期：0
• ISSN：1523-7052

文摘

Peptides and peptidomimetics with a C-terminal boronic acid group have prolific applications in numerous fields of research, but their synthetic accessibility remains problematic. A convenient, high yield synthesis of peptide-boronic acids on a solid support is described here, using commercially available 1-glycerol polystyrene resin. The method is compatible with Fmoc chemistry and offers a versatile approach to aryl and alkyl aminoboronic acids without additional purification steps.