Isolation and Structures of Axistatins 1鈥? from the Republic of Palau Marine Sponge Agelas axifera Hentschel

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• 作者：George R. Pettit ; Yuping Tang ; Qingwen Zhang ; Gregory T. Bourne ; Christoph A. Arm ; John E. Leet ; John C. Knight ; Robin K. Pettit ; Jean-Charles Chapuis ; Dennis L. Doubek ; Franklin J. Ward ; Christine Weber ; John N. A. Hooper
• 刊名：Journal of Natural Products
• 出版年：2013
• 出版时间：March 22, 2013
• 年：2013
• 卷：76
• 期：3
• 页码：420-424
• 全文大小：245K
• 年卷期：v.76,no.3(March 22, 2013)
• ISSN：1520-6025

文摘

An investigation begun in 1979 directed at the Republic of Palau marine sponge Agelas axifera Hentschel for cancer cell growth inhibitory constituents subsequently led to the isolation of three new pyrimidine diterpenes designated axistatins 1 (1), 2 (2), and 3 (3), together with the previously reported formamides 4, 5, and agelasine F (6). The structures were elucidated by analysis of 2D-NMR spectra and by HRMS. All of the isolated compounds were found to be moderate inhibitors of cancer cell growth. Axistatins 1鈥? (1鈥?b>3), formamide 4, and agelasine F (6) also exhibited antimicrobial activity.