Path Dependence of Three-Phase or Two-Phase End Points in Fluid Binary Lipid Mixtures

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• 作者：Emily R. Lamberson^† ; ; Lee R. Cambrea^† ; ; Jean-Christophe Rochet^‡ ; ; Jennifer S. Hovis*^† ;
• 刊名：Journal of Physical Chemistry B
• 出版年：2009
• 出版时间：March 19, 2009
• 年：2009
• 卷：113
• 期：11
• 页码：3431-3436
• 全文大小：319K
• 年卷期：v.113,no.11(March 19, 2009)
• ISSN：1520-5207

文摘

The phase behavior of anionic/zwitterionic mixtures can be controlled by tuning the charge state of the anionic lipid. In the case of dioleoylphosphatidic acid (DOPA)/dioleoylphosphatidylcholine (DOPC) mixtures, demixing occurs either when DOPA is protonated or when DOPA²⁻:Ca²⁺ complexes form. Herein it will be shown that the final end point, a three-phase or two-phase system, depends on the order in which the charge state is manipulated. The facile accessibility of different end points is a clear demonstration of the inherent flexibility of biological systems.