Enantioselective Syntheses of α-Fmoc-Pbf-[2-13C]-l-arginine and Fmoc-[1,3-13C2]-l-proline and Incorp

详细信息    查看全文

• 作者：Chuanjun Song ; Satita Tapaneeyakorn ; Annabel C. Murphy ; Craig Butts ; Anthony Watts ; Christine L. Willis
• 刊名：Journal of Organic Chemistry
• 出版年：2009
• 出版时间：December 4, 2009
• 年：2009
• 卷：74
• 期：23
• 页码：8980-8987
• 全文大小：829K
• 年卷期：v.74,no.23(December 4, 2009)
• ISSN：1520-6904

文摘

Enantioselective syntheses of selectively labeled, orthogonally protected [2-¹³C]-l-arginine and [1,3-¹³C₂]-l-proline are described from the commercially available precursors [2-¹³C]bromoacetic acid and potassium [¹³C]cyanide. Interestingly the enhanced signal assigned to C-2 in the ¹³C NMR spectrum of α-Fmoc-Pbf-[2-¹³C]-l-arginine was very broad at room temperature. The two Fmoc-labeled amino acids were used to prepare [2-¹³C]-Arg9 and [1,3-¹³C₂]-Pro10 labeled ligand (NT₈₋₁₃) by manual Fmoc-SPSS.