Rhodium(III)-Catalyzed Selective Monoarylation of β or γ C(sp3)–H Bonds Assisted by a Trimethylpyrazole Group

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• 作者：Chunchen Yuan ; Guangliang Tu ; Yingsheng Zhao
• 刊名：Organic Letters
• 出版年：2017
• 出版时间：January 20, 2017
• 年：2017
• 卷：19
• 期：2
• 页码：356-359
• 全文大小：439K
• ISSN：1523-7052

文摘

The selective arylation of unactivated β or challenging γ primary and secondary β-C(sp<sup>3sup>)–H bonds has been developed with a Cp*Rh(III) catalyst assisted by a trimethylpyrazole group. A rarely reported six-membered rhodacycle has been identified in rhodium-catalyzed C(sp<sup>3sup>)–H activation reactions. Preliminary mechanistic studies have revealed that a concerted metalation–deprotonation pathway might be involved in the C–H activation step.