Diterpenes from the Trunk of Abies holophylla and Their Potential Neuroprotective and Anti-inflammatory Activities
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- 作者：Chung Sub Kim ; Lalita Subedi ; Sun Yeou Kim ; Sang Un Choi ; Ki Hyun Kim ; Kang Ro Lee
- 刊名：Journal of Natural Products
- 出版年：2016
- 出版时间：February 26, 2016
- 年：2016
- 卷：79
- 期：2
- 页码：387-394
- 全文大小：364K
- ISSN：1520-6025
文摘
Eleven new abietane-type diterpenes, holophyllins D–N (1–11), and 17 known analogues (12–28), were isolated from a MeOH extract of the trunk of Abies holophylla. The chemical structures of 1–11 were determined through spectroscopic data analysis, including NMR (<sup>1sup>H and <sup>13sup>C NMR, DEPT, <sup>1sup>H–<sup>1sup>H COSY, HMQC, HMBC, and NOESY) and HRFABMS methods. All isolated compounds (1–28) were evaluated for their cytotoxicity against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-116), for their potential neuroprotective effects through induction of nerve growth factor in C6 glioma cells, and for their effects on nitric oxide levels in lipopolysaccharide-stimulated murine microglia BV2 cells.