Bioinspired Porous ZnO Nanomaterials from Fungal Polysaccharides: Advanced Materials with Unprecedented Low Toxicity in Vitro for Human Cells

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• 作者：Chunping Xu ; Manuel Ojeda ; Rick A. D. Arancon ; Antonio A. Romero ; Jos茅 Luis Domingo ; Mercedes G贸mez ; Jordi Blanco ; Rafael Luque
• 刊名：ACS Sustainable Chemistry & Engineering
• 出版年：2015
• 出版时间：November 2, 2015
• 年：2015
• 卷：3
• 期：11
• 页码：2716-2725
• 全文大小：663K
• ISSN：2168-0485

文摘

Mechanochemically synthesized ZnO鈥損olysaccharide nanohybrids prepared from fungal polysaccharides were proved to exhibit remarkable surface properties and structures for biomedical applications. The synthesized ZnO nanomaterials possessed an unprecedented low cytotoxicity against human cell lines A549 and SH-SY5Y (EC50: 50鈥?00 渭g mL^鈥?) as compared to commercial ZnO nanomaterials due to the stability and low release of Zn²⁺ and reduced interaction nanoparticle/cells due to the high biocompatibility of the nanohybrids.