Palladium-Catalyzed Cross-Coupling of Cyclopropylmagnesium Bromide with Aryl Bromides Mediated by Zinc Halide Additives
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- 作者：Chutian Shu ; Kanwar Sidhu ; Li Zhang ; Xiao-jun Wang ; Dhileepkumar Krishnamurthy ; Chris H. Senanayake
- 刊名：Journal of Organic Chemistry
- 出版年：2010
- 出版时间：October 1, 2010
- 年：2010
- 卷：75
- 期：19
- 页码：6677-6680
- 全文大小：727K
- 年卷期：v.75,no.19(October 1, 2010)
- ISSN：1520-6904
文摘
The key Pd-catalyzed cross-coupling of aryl bromides or triflates and cyclopropylmagnesium bromide in the presence of substoichiometric amounts of zinc bromide produces cyclopropyl arenes in good to excellent yields. The cross-coupling of other alkyl, cycloalkyl, and aryl Grignard reagents with aryl bromides under the same conditions gives the corresponding substituted arenes in good yields.