NASR: An Effective Approach for Simultaneous Noise and Artifact Suppression in NMR Spectroscopy

详细信息    查看全文

• 作者：Bin Jiang ; Fan Luo ; Yiming Ding ; Peng Sun ; Xu Zhang ; Ling Jiang ; Conggang Li ; Xi-an Mao ; Daiwen Yang ; Chun Tang ; Maili Liu
• 刊名：Analytical Chemistry
• 出版年：2013
• 出版时间：February 19, 2013
• 年：2013
• 卷：85
• 期：4
• 页码：2523-2528
• 全文大小：335K
• 年卷期：v.85,no.4(February 19, 2013)
• ISSN：1520-6882

文摘

As a powerful tool for biological analysis, especially protein structure and dynamic studies, nuclear magnetic resonance (NMR) spectroscopy suffers from intrinsic low signal to nose ratio (SNR) and long acquisition time required for multidimensional (nD) experiments. Nonuniform sampling (NUS) can effectively speed up the experiment but often introduces artifacts into the spectrum. In addition to the development of highly sensitive hardware and NMR pulse sequences, data postprocessing is a relative simple and cost-effective method to improve the SNR and suppress the artifacts. In this work, we propose an effective approach for simultaneously suppressing noise and artifacts based on the resampling principle. The method is named NASR for short and tested using one-, two-, and three-dimensional (1D, 2D, and 3D) NMR spectra that were acquired using ether conventional or NUS (spiral and random, for 3D) approaches. The results reveal that the NASR is fast and applicable for improving the quality of 1D to nD NMR spectra with all kinds of sampling schemes.