Design and Synthesis of Orally Bioavailable Benzimidazoles as Raf Kinase Inhibitors
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- 作者：Savithri Ramurthy ; Sharadha Subramanian ; Mina Aikawa ; Payman Amiri ; Abran Costales ; Jeff Dove ; Susan Fong ; Johanna M. Jansen ; Barry Levine ; Sylvia Ma ; Christopher M. McBride ; Jonah Michaelian ; Teresa
- 刊名：Journal of Medicinal Chemistry
- 出版年：2008
- 出版时间：November 27, 2008
- 年：2008
- 卷：51
- 期：22
- 页码：7049-7052
- 全文大小：176K
- 年卷期：v.51,no.22(November 27, 2008)
- ISSN：1520-4804
文摘
A series of arylaminobenzimidazoles was designed and synthesized as Raf kinase inhibitors. Exploration of the structure−activity relationship resulted in compounds that are potent in vitro and show desirable in vivo properties.