Englerin A, a Selective Inhibitor of Renal Cancer Cell Growth, from Phyllanthus engleri

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• 作者：Ranjala Ratnayake ; David Covell ; Tanya T. Ransom ; Kirk R. Gustafson ; John A. Beutler
• 刊名：Organic Letters
• 出版年：2009
• 出版时间：January 1, 2009
• 年：2009
• 卷：11
• 期：1
• 页码：57-60
• 全文大小：150K
• 年卷期：v.11,no.1(January 1, 2009)
• ISSN：1523-7052

文摘

An extract from Phyllanthus engleri was identified in a bioinformatic analysis of NCI 60-cell natural product extract screening data that selectively inhibited the growth of renal cancer cell lines. Bioassay-guided fractionation yielded two new guaiane sesquiterpenes, englerins A (1) and B (2). Englerin A showed 1000-fold selectivity against six of eight renal cancer cell lines with GI₅₀ values ranging from 1−87 nM. The structures of 1 and 2 and their relative stereochemistry were established by spectroscopic methods.