Antinociceptive Properties of Physalins from Physalis angulata

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• 作者：Milena da Silva Lima ; Afr芒nio Ferreira Evangelista ; Gisele Gra莽a Leite dos Santos ; Ivone Maria Ribeiro ; Therezinha Coelho Barbosa Tomassini ; Milena Botelho Pereira Soares ; Cristiane Flora Villarreal
• 刊名：Journal of Natural Products
• 出版年：2014
• 出版时间：November 26, 2014
• 年：2014
• 卷：77
• 期：11
• 页码：2397-2403
• 全文大小：385K
• ISSN：1520-6025

文摘

Pain is the most common reason a patient sees a physician. Nevertheless, the use of typical painkillers is not completely effective in controlling all pain syndromes; therefore further attempts have been made to develop improved analgesic drugs. The present study was undertaken to evaluate the antinociceptive properties of physalins B (1), D (2), F (3), and G (4) isolated from Physalis angulata in inflammatory and centrally mediated pain tests in mice. Systemic pretreatment with 1鈥?b>4 produced dose-related antinociceptive effects on the writhing and formalin tests, traditional screening tools for the assessment of analgesic drugs. On the other hand, only 3 inhibited inflammatory parameters such as hyperalgesia, edema, and local production of TNF-伪 following induction with complete Freund鈥檚 adjuvant. Treatment with 1, 3, and 4 produced an antinociceptive effect on the tail flick test, suggesting a centrally mediated antinociception. Reinforcing this idea, 2鈥?b>4 enhanced the mice latency reaction time during the hot plate test. Mice treated with physalins did not demonstrate motor performance alterations. These results suggest that 1鈥?b>4 present antinociceptive properties associated with central, but not anti-inflammatory, events and indicate a new pharmacological property of physalins.