Four-Coordinate Dimethylgallium Compounds Vary in Stability toward Hydrolysis
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- 作者：Robert W. Chesnut ; Richard R. Cesati ; III ; Cathy S. Cutler ; Sara L. Pluth ; and John A. Katzenellenbogen
- 刊名：Organometallics
- 出版年：1998
- 出版时间：October 26, 1998
- 年：1998
- 卷：17
- 期：22
- 页码：4889 - 4896
- 全文大小：106K
- 年卷期：v.17,no.22(October 26, 1998)
- ISSN：1520-6041
文摘
Four-coordinate dimethylgallium complexes were prepared by the reaction of dimethylgallium hydroxide with bidentate Lewis bases and evaluated for their stability towarddecomplexation in water, a key property in determining their potential usefulness asradiopharmaceuticals, particularly those targeted at specific receptor proteins. Modelcompounds from six structural classes, containing bidentate ligands with oxygen-oxygen,oxygen-nitrogen, and sulfur-nitrogen donor atoms, were prepared from the ligand anddimethylgallium hydroxide; they were characterized spectroscopically and, in two cases, byX-ray crystallography. The percentage decomplexation of the stable (CH3)2Ga+ unit fromthe Lewis base when exposed to 1000 equiv of water in acetone-d6, determined by 1H NMR,was used as a measure of the relative hydrolytic stability of each compound. Among thecompounds we have investigated, the percent hydrolysis under these conditions ranged from10% to 100%, the most hydrolytically stable compounds proving to be those based on anN-alkylsalicylaldimidate donor.