Activation of Functional Arylzincs Prepared from Aryl Iodides and Highly Enantioselective Addition to Aldehydes
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- 作者：Albert M. DeBerardinis ; Mark Turlington ; Lin Pu
- 刊名：Organic Letters
- 出版年：2008
- 出版时间：July 3, 2008
- 年：2008
- 卷：10
- 期：13
- 页码：2709 - 2712
- 全文大小：116K
- 年卷期：v.10,no.13(July 3, 2008)
- ISSN：1523-7052
文摘
An easily available chiral ligand (S)-1 is found to activate the nucleophilic reaction of the arylzincs prepared in situ from the reaction of aryl iodides with Et2Zn. Both high yields and high enantioselectivity (up to >99% ee) for the reaction of these arylzincs with a variety of aldehydes are obtained. The mild reaction conditions and the good functional group tolerance make this catalytic asymmetric process synthetically useful.