Using Esters To Introduce Paradigms of Spin–Spin Coupling
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- 作者：Kyle T. Smith ; Christian S. Hamann
- 刊名：Journal of Chemical Education
- 出版年：2017
- 出版时间：January 10, 2017
- 年：2017
- 卷：94
- 期：1
- 页码：126-130
- 全文大小：235K
- ISSN：1938-1328
文摘
Students analyzed a set of 34 carboxylic esters using 1H nuclear magnetic resonance (NMR) spectroscopy to examine paradigmatic examples of spin–spin coupling, a foundational concept used to determine molecular structure by NMR spectroscopy. The ester functional group provides excellent chemical shift dispersion so that students were able to analyze well-resolved peaks and to apply concepts of chemical shift, line shape, and integration to the analysis of molecular substructures. A laboratory activity combining molecular models, worksheets, and NMR data collection and analysis provided students with the ability to predict and to analyze spectra representing spin–spin splitting for N = 0–6 (where N is the number of three-bond neighbors that are hydrogens).