Palladium-Catalyzed Oxidative Synthesis of Unsymmetrical Azophenols

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• 作者：Thi Hong Long Nguyen ; Nicolas Gigant ; Sandrine Delarue-Cochin ; Delphine Joseph
• 刊名：Journal of Organic Chemistry
• 出版年：2016
• 出版时间：March 4, 2016
• 年：2016
• 卷：81
• 期：5
• 页码：1850-1857
• 全文大小：475K
• ISSN：1520-6904

文摘

A straightforward palladium-catalyzed oxidative hydroxylation of azobenzenes is reported. The developed methodology tolerates various functional groups and allows the synthesis of diverse unsymmetrical azophenols under mild conditions in good to excellent yields. A complementary procedure was also investigated by in situ generation of PIFA. This study represents the first general method for the synthesis of o-hydroxyazobenzenes starting from simple azoarenes.