Atomic Structure of a Short -Helix Stabilized by a Main Chain Hydrogen-Bond Surrogate
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- 作者：Jie Liu ; Deyun Wang ; Qi Zheng ; Min Lu ; Paramjit S. Arora
- 刊名：Journal of the American Chemical Society
- 出版年：2008
- 出版时间：April 2, 2008
- 年：2008
- 卷：130
- 期：13
- 页码：4334 - 4337
- 全文大小：302K
- 年卷期：v.130,no.13(April 2, 2008)
- ISSN：1520-5126
文摘
Herein we report the 1.15 Å X-ray crystal structure of a short 
-helix in which the N-terminal iand i + 4 main chain hydrogen bond is replaced with a carbon-carbon bond. The structure shows that thehydrogen-bond surrogate (HBS) derived -helix truly resembles the structure of canonical -helices andprovides unequivocal support for our helix nucleation strategy.
-helix in which the N-terminal iand i + 4 main chain hydrogen bond is replaced with a carbon-carbon bond. The structure shows that thehydrogen-bond surrogate (HBS) derived -helix truly resembles the structure of canonical -helices andprovides unequivocal support for our helix nucleation strategy.