Unique Tandem Heck-Lactamization Naphthyridinone Ring Formation between Acrylanilides and Halogenated Pyridines

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• 作者：Raymond J. Cvetovich ; Robert A. Reamer ; Lisa DiMichele ; John Y. L. Chung ; Jennifer R. Chilenski
• 刊名：Journal of Organic Chemistry
• 出版年：2006
• 出版时间：October 27, 2006
• 年：2006
• 卷：71
• 期：22
• 页码：8610 - 8613
• 全文大小：86K
• 年卷期：v.71,no.22(October 27, 2006)
• ISSN：1520-6904

文摘

The Heck coupling of acrylanilides with 4-bromo-2-chloro-3-iodo-pyridine using palladium acetate can producebis-Heck products or undergo an unusual tandem Heck-lactamization ring formation to generate 5-chloro-1-aryl-1,6-naphthyridin-2(1H)-ones.