Vilsmeier Reaction of Enaminones: Efficient Synthesis of Halogenated Pyridin-2(1H)-ones

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• 作者：Rui Zhang ; Dingyuan Zhang ; Yongli Guo ; Guangyuan Zhou ; Zijiang Jiang ; Dewen Dong
• 刊名：Journal of Organic Chemistry
• 出版年：2008
• 出版时间：December 5, 2008
• 年：2008
• 卷：73
• 期：23
• 页码：9504-9507
• 全文大小：186K
• 年卷期：v.73,no.23(December 5, 2008)
• ISSN：1520-6904

文摘

A facile and efficient one-pot synthesis of halogenated pyridin-2(1H)-ones from a series of readily available enaminones under Vilsmeier conditions is described, and a mechanism involving sequential halogenation, formylation, and intramolecular nucleophilic cyclization is proposed.