文摘
A series of oligosaccharides (cellobio-oligosaccharides) ranging from degrees of polymer 3 to 6 were synthesized by Leuconostoc mesenteroides B-512 FMCM in the presence of cellobiose. The major oligosaccharides were the trisaccharides, α-d-glucopyranosyl-(1→2)-β-d-glucopyranosyl-(1→4)-d-glucopyranose and α-d-glucopyranosyl-(1→6)-β-d-glucopyranosyl-(1→4)-d-glucopyranose. These cellobio-oligosaccharides were inhibitory on mutansucrase, an enzyme that causes dental caries. They were also found to be effective antifungal agents against Aspergillus terreus acting by inhibiting β-(1→3)-glucan synthase, which is required for fungal cell wall formation.
Keywords (keywords):
Oligosaccharides; cellobiose; dextransucrase; Aspergillus terreus; dental plaque; antifungal agent