Potential Physiological Functions of Acceptor Products of Dextransucrase with Cellobiose as an Inhibitor of Mutansucrase and Fungal Cell Synthase
详细信息 查看全文
- 作者：Misook Kim ; Donal F. Day ; Doman Kim
- 刊名：Journal of Agricultural and Food Chemistry
- 出版年：2010
- 出版时间：November 10, 2010
- 年：2010
- 卷：58
- 期：21
- 页码：11493-11500
- 全文大小：967K
- 年卷期：v.58,no.21(November 10, 2010)
- ISSN：1520-5118
文摘
A series of oligosaccharides (cellobio-oligosaccharides) ranging from degrees of polymer 3 to 6 were synthesized by Leuconostoc mesenteroides B-512 FMCM in the presence of cellobiose. The major oligosaccharides were the trisaccharides, α-d-glucopyranosyl-(1→2)-β-d-glucopyranosyl-(1→4)-d-glucopyranose and α-d-glucopyranosyl-(1→6)-β-d-glucopyranosyl-(1→4)-d-glucopyranose. These cellobio-oligosaccharides were inhibitory on mutansucrase, an enzyme that causes dental caries. They were also found to be effective antifungal agents against Aspergillus terreus acting by inhibiting β-(1→3)-glucan synthase, which is required for fungal cell wall formation.