Debromodispacamides B and D: Isolation from the Marine Sponge Agelas mauritiana and Stereoselective Synthesis Using a Biomimetic Proline Route

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• 作者：Carine Vergne ; J&eacute ; rô ; me Appenzeller ; C&eacute ; line Ratinaud ; Marie-Th&eacute ; rè ; se Martin ; C&eacute ; cile Debitus ; Anne Zaparucha ; Ali Al-Mourabit
• 刊名：Organic Letters
• 出版年：2008
• 出版时间：February 7, 2008
• 年：2008
• 卷：10
• 期：3
• 页码：493 - 496
• 全文大小：68K
• 年卷期：v.10,no.3(February 7, 2008)
• ISSN：1523-7052

文摘

LE>l702866mn00002>ls/orlef7/10/i03/figures/ol702866mn00002.gif" ALIGN="left" HSPACE=5>New debromopyrrole-2-aminoimidazolones, debromodispacamide B (1) and debromodispacamide D (2) were isolated from the sponge Agelasmauritiana, collected in the Solomon Islands. A biomimetic one-step reaction from pseudopeptides 5 and 13 in presence of air oxygen andguanidine gave the chiral form of the natural product stereoselectively.