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The pot, atom, and step-economic synthesis of Rosettacintopo-I poison and its derivatives has been achieved using anovel domino
N-amidoacylation/aldol-type condensation,followed by decarboxylation of the ester function. The keydomino procedure simply involves mixing HOBt ester asnew reagent with lactam and NaH together in THF or THF/DMF. The reaction seems to be general and led to suitable
N-heterocyclic products in moderate to good yields.