Allosteric Modulation of Substrate Binding within a Tetracationic Molecular Receptor
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- 作者：James J. Henkelis ; Anthea K. Blackburn ; Edward J. Dale ; Nicolaas A. Vermeulen ; Majed S. Nassar ; J. Fraser Stoddart
- 刊名：Journal of the American Chemical Society
- 出版年：2015
- 出版时间：October 21, 2015
- 年：2015
- 卷：137
- 期：41
- 页码：13252-13255
- 全文大小：355K
- ISSN：1520-5126
文摘
The synthesis and recognition phenomena of a tetracationic molecular receptor that possesses a nanometer-sized molecular cavity are described. The host鈥揼uest properties of the molecular receptor can be tuned and modulated allosterically, where the association of a heterotropic effector at the periphery of the molecule serves to modulate its affinity for the globular, electron-rich guest that resides within its molecular cavity. This stimuli-responsive host鈥揼uest behavior was observed in both the solution phase and the crystalline solid state, and can be reversed with high fidelity by sequestration of the effector molecule.