Anti-inflammatory Thiazine Alkaloids Isolated from the New Zealand Ascidian Aplidium sp.: Inhibitors of the Neutrophil Respiratory Burst in a Model of Gouty Arthritis
详细信息 查看全文
- 作者：A. Norrie Pearce ; Elizabeth W. Chia ; Michael V. Berridge ; George R. Clark ; Jacquie L. Harper ; Lesley Larsen ; Elizabeth W. Maas ; Michael J. Page ; Nigel B. Perry ; Victoria L. Webb ; Brent R. Copp
- 刊名：Journal of Natural Products
- 出版年：2007
- 出版时间：June 2007
- 年：2007
- 卷：70
- 期：6
- 页码：936 - 940
- 全文大小：81K
- 年卷期：v.70,no.6(June 2007)
- ISSN：1520-6025
文摘
Ascidiathiazones A (3) and B (4), two new tricyclic thiazine-containing quinolinequinone alkaloids, were isolated fromthe New Zealand ascidian Aplidium species. Both compounds inhibited the in vitro production of superoxide by PMA-stimulated human neutrophils in a dose-dependent manner with IC50 1.55 ± 0.32 and 0.44 ± 0.09 
M, respectively. Invivo inhibition of superoxide production by peritoneal neutrophils in a murine model of gout was observed for bothcompounds with oral doses of 25.6 mol/kg. Ascidiathiazone A (3) was synthesized in four steps from 8-hydroxyquinoline-2-carboxylic acid.
M, respectively. Invivo inhibition of superoxide production by peritoneal neutrophils in a murine model of gout was observed for bothcompounds with oral doses of 25.6 mol/kg. Ascidiathiazone A (3) was synthesized in four steps from 8-hydroxyquinoline-2-carboxylic acid.