Integrin Cytoplasmic Tail Interactions

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• 作者：Elizabeth M. Morse ; Nina N. Brahme ; David A. Calderwood
• 刊名：Biochemistry
• 出版年：2014
• 出版时间：February 11, 2014
• 年：2014
• 卷：53
• 期：5
• 页码：810-820
• 全文大小：531K
• ISSN：1520-4995

文摘

Integrins are heterodimeric cell surface adhesion receptors essential for multicellular life. They connect cells to the extracellular environment and transduce chemical and mechanical signals to and from the cell. Intracellular proteins that bind the integrin cytoplasmic tail regulate integrin engagement of extracellular ligands as well as integrin localization and trafficking. Cytoplasmic integrin-binding proteins also function downstream of integrins, mediating links to the cytoskeleton and to signaling cascades that impact cell motility, growth, and survival. Here, we review key integrin-interacting proteins and their roles in regulating integrin activity, localization, and signaling.