Role of N-Acyl Amino Acid Ligands in Pd(II)-Catalyzed Remote C–H Activation of Tethered Arenes
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- 作者：Gui-Juan Cheng ; Yun-Fang Yang ; Peng Liu ; Ping Chen ; Tian-Yu Sun ; Gang Li ; Xinhao Zhang ; K. N. Houk ; Jin-Quan Yu ; Yun-Dong Wu
- 刊名：Journal of the American Chemical Society
- 出版年：2014
- 出版时间：January 22, 2014
- 年：2014
- 卷：136
- 期：3
- 页码：894-897
- 全文大小：285K
- ISSN：1520-5126
文摘
A combined experimental/computational study on the amino acid ligand-assisted Pd-catalyzed C鈥揌 bond activation reveals a mechanism in which the amino acid acts as both a dianionic bidentate ligand and a proton acceptor. This new model explains the effects of amino acids on reactivity and selectivity and unveils the dual roles of amino acids: stabilizing monomeric Pd complexes and serving as the internal base for proton abstraction.