Highly Regioselective Halogenation of Pyridine N-Oxide: Practical Access to 2-Halo-Substituted Pyridines

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• 作者：Ying Chen ; Jinkun Huang ; Tsang-Lin Hwang ; Maosheng J. Chen ; Jason S. Tedrow ; Robert P. Farrell ; Matthew M. Bio ; Sheng Cui
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：June 19, 2015
• 年：2015
• 卷：17
• 期：12
• 页码：2948-2951
• 全文大小：260K
• ISSN：1523-7052

文摘

A highly efficient and regioselective halogenation reaction of unsymmetrical pyridine N-oxide under mild conditions is described. The methodology provides a practical access to various 2-halo-substituted pyridines, which are pharmaceutically important intermediates.