Forsythoneosides A鈥揇, Neuroprotective Phenethanoid and Flavone Glycoside Heterodimers from the Fruits of Forsythia suspensa

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• 作者：Fan Zhang ; Ya-Nan Yang ; Xiu-Yun Song ; Si-Yuan Shao ; Zi-Ming Feng ; Jian-Shuang Jiang ; Li Li ; Nai-Hong Chen ; Pei-Cheng Zhang
• 刊名：Journal of Natural Products
• 出版年：2015
• 出版时间：October 23, 2015
• 年：2015
• 卷：78
• 期：10
• 页码：2390-2397
• 全文大小：407K
• ISSN：1520-6025

文摘

Forsythoneosides A鈥揇 (1鈥?b>4), four unusual adducts of a flavonoid unit fused to a phenylethanoid glycoside through a pyran ring or carbon鈥揷arbon bond, and four new phenylethanoid glycosides (5鈥?b>8) were isolated from the fruits of Forsythia suspensa, together with nine known compounds. The structures of 1鈥?b>8, including their absolute configurations, were elucidated by spectroscopic data as well as experimental and calculated electronic circular dichroism analysis. Compounds 2 and 4 inhibited PC12 cell damage induced by rotenone, and increased cell viability from 53.9 卤 7.1% to 70.1 卤 4.0% and 67.9 卤 5.2% at 0.1 渭M, respectively.