New Butyrolactone Type Lignans from Arctii Fructus and Their Anti-inflammatory Activities

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• 作者：Ya-Nan Yang ; Xiao-Ying Huang ; Zi-Ming Feng ; Jian-Shuang Jiang ; Pei-Cheng Zhang
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2015
• 出版时间：September 16, 2015
• 年：2015
• 卷：63
• 期：36
• 页码：7958-7966
• 全文大小：320K
• ISSN：1520-5118

文摘

Arctiidilactone (1), a novel rare butyrolactone lignan with a 6-carboxyl-2-pyrone moiety, and 11 new butyrolactone lignans (2鈥?b>12) were isolated from the fruits of Arctium lappa L., together with 5 known compounds (13鈥?b>17). Their structures were elucidated by interpretation of their spectroscopic data (1D and 2D NMR, UV, IR, ORD, and HRESIMS) and comparison to literature data. The absolute configurations of compounds 1鈥?b>12 were determined by a combination of rotating-frame nuclear Overhauser effect spectroscopy (ROESY), circular dichroism (CD) spectroscopy, and Rh₂(OCOCF₃)₄-induced CD spectroscopy. All of the compounds were tested for their anti-inflammatory properties in terms of suppressing the production of NO in lipopolysaccharide-induced BV2 cells. Compounds 1, 6, 8, and 10 exhibited stronger anti-inflammatory effects than the positive control curcumin, particularly 1, which exhibited 75.51, 70.72, and 61.17% inhibition at 10, 1, and 0.1 渭M, respectively.