Solubility of Cefpiramide Sodium in Binary Ethanol + Water and 2-Propanol + Water Solvent Mixtures

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• 作者：Fengxiang Tang ; Shan Wu ; Fuqiang Wu ; Suying Zhao
• 刊名：Journal of Chemical & Engineering Data
• 出版年：2014
• 出版时间：January 9, 2014
• 年：2014
• 卷：59
• 期：1
• 页码：56-60
• 全文大小：271K
• ISSN：1520-5134

文摘

The solubility of cefpiramide sodium in binary solvent mixtures of ethanol + water and 2-propanol + water was determined by a steady-state method from (278.2 to 303.2) K and in the initial mole fraction range of alcohol (ethanol or 2-propanol) in the solvent mixture at about 0.4 to 0.8. Cefpiramide sodium exhibits the same order of magnitude of solubility in both binary systems. The solubility decreases with the increase of the initial mole fraction of alcohol and increases with increasing temperature. Dilution crystallization or dilution crystallization incorporated with cooling crystallization will be more suitable than pure cooling crystallization for the purification of cefpiramide sodium. The Jouyban鈥揂cree model, combined with the van鈥檛 Hoff equation, was used to correlate the solubility data. The combined model was further simplified so that each item in the model is statistically significant at the 5 % level. The simplified combined model gives a mean relative deviation of 5.3 % for the ethanol + water system, and 3.0 % for the 2-propanol + water system. This model demonstrates good fitting with the experimental solubility data, and could be used for related process design in the pharmaceutical industry.