A General Method for the Synthesis of Unsymmetrically Substituted Ureas via Palladium-Catalyzed Amidation

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• 作者：Brian J. Kotecki* ; Dilinie P. Fernando ; Anthony R. Haight ; Kirill A. Lukin
• 刊名：Organic Letters
• 出版年：2009
• 出版时间：February 19, 2009
• 年：2009
• 卷：11
• 期：4
• 页码：947-950
• 全文大小：151K
• 年卷期：v.11,no.4(February 19, 2009)
• ISSN：1523-7052

文摘

A general and practical method for the preparation of unsymmetrically substituted ureas has been developed utilizing palladium-catalyzed amidation. Both aryl bromides and chlorides, as well as heteroaryl chlorides, have been coupled to aryl, benzyl, and aliphatic ureas by using a novel nonproprietary bipyrazole ligand (bippyphos).