Hydroxyclerodanes from Salvia shannoni

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• 作者：Elih煤 Bautista ; Alfredo Toscano ; Fernando Calzada ; Eduardo D铆az ; Lilian Y茅pez-Mulia ; Alfredo Ortega
• 刊名：Journal of Natural Products
• 出版年：2013
• 出版时间：October 25, 2013
• 年：2013
• 卷：76
• 期：10
• 页码：1970-1975
• 全文大小：281K
• 年卷期：v.76,no.10(October 25, 2013)
• ISSN：1520-6025

文摘

Six new hydroxyclerodanes (1鈥?b>6), named sepulturins A鈥揊, and four known diterpenes were isolated from the leaves of Salvia shannoni. The structures of these compounds were established by extensive analysis of their NMR and MS spectroscopic data. The relative configurations of compounds 1 and 2 were determined by NOESY experiments and were confirmed by single-crystal X-ray diffraction studies. All of the isolated diterpenes possess tertiary OH groups. The structure of infuscatin (7), a clerodane previously isolated from S. infuscata, was revised. Cytotoxic, antiprotozoal, and anti-inflammatory activities of these compounds were evaluated.