Substitution Effect on the One- and Two-photon Sensitivity of DMAQ 鈥淐aging鈥?Groups
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- 作者：Morgane Petit ; Christine Tran ; Thomas Roger ; Thibault Gallavardin ; Hamid Dhimane ; Francisco Palma-Cerda ; Mireille Blanchard-Desce ; Francine C. Acher ; David Ogden ; Peter I. Dalko
- 刊名：Organic Letters
- 出版年：2012
- 出版时间：December 21, 2012
- 年：2012
- 卷：14
- 期：24
- 页码：6366-6369
- 全文大小：242K
- 年卷期：v.14,no.24(December 21, 2012)
- ISSN：1523-7052
文摘
The systematic SAR study of a 鈥渃aging鈥?group showed a strong influence of the position of the donor dimethylamino group on the efficiency of photolysis of the DMAQ (2-hydroxymethylene-(N,N-dimethylamino)quinoline) caged acetate under one-photon near-UV or two-photon near-IR excitation. Photorelease of l-glutamate by the most efficient 8-DMAQ derivative strongly and efficiently activated glutamate receptors, generating large, fast rising responses similar to those elicited by glutamate photoreleased from the widely used MNI-caged glutamate.