Seven New Microcystins Possessing Two L-Glutamic Acid Units, Isolated from Anabaena sp. Strain 186
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- 作者：Michio Namikoshi ; Moucun Yuan ; Kaarina Sivonen ; Wayne W. Carmichael ; Kenneth L. Rinehart ; Leo Rouhiainen ; Furong Sun ; Scott Brittain ; and Akira Otsuki
- 刊名：Chemical Research in Toxicology
- 出版年：1998
- 出版时间：February 1998
- 年：1998
- 卷：11
- 期：2
- 页码：143 - 149
- 全文大小：149K
- 年卷期：v.11,no.2(February 1998)
- ISSN：1520-5010
文摘
Electrospray ionization mass spectrometry has been applied to thestructure assignment ofseven new microcystins (1-7), obtained fromcultured Anabaena sp. strain 186. Thesevennew microcystins contain the dehydroalanine (Dha) or L-Serunit instead of the N-methyldehydroalanine unit and the L-Glu and/or its 
-methyl ester[E(OMe)] units at the two variableL-amino acid units, and the structures were assigned as[Dha7]microcystin-E(OMe)E(OMe)(1),[D-Asp3,Dha7]microcystin-E(OMe)E(OMe)(2),[L-Ser7]microcystin-E(OMe)E(OMe)(3),[D-Asp3,L-Ser7]microcystin-E(OMe)E(OMe) (4),[Dha7]microcystin-EE(OMe) (5),[D-Asp3,Dha7]microcystin-EE(OMe) (6), and[L-Ser7]microcystin-EE(OMe)(7). These microcystins are the firstexamplescontaining dicarboxylic amino acids at the two variableL-amino acid units in microcystins.
-methyl ester[E(OMe)] units at the two variableL-amino acid units, and the structures were assigned as[Dha7]microcystin-E(OMe)E(OMe)(1),[D-Asp3,Dha7]microcystin-E(OMe)E(OMe)(2),[L-Ser7]microcystin-E(OMe)E(OMe)(3),[D-Asp3,L-Ser7]microcystin-E(OMe)E(OMe) (4),[Dha7]microcystin-EE(OMe) (5),[D-Asp3,Dha7]microcystin-EE(OMe) (6), and[L-Ser7]microcystin-EE(OMe)(7). These microcystins are the firstexamplescontaining dicarboxylic amino acids at the two variableL-amino acid units in microcystins.