Abibalsamins A and B, Two New Tetraterpenoids from Abies balsamea Oleoresin

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• 作者：Serge Lavoie ; Jean Legault ; Charles Gauthier ; Vakhtang Mshvildadze ; Sylvain Mercier ; Andr茅 Pichette
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：March 16, 2012
• 年：2012
• 卷：14
• 期：6
• 页码：1504-1507
• 全文大小：253K
• 年卷期：v.14,no.6(March 16, 2012)
• ISSN：1523-7052

文摘

Abibalsamins A (1) and B (2), two unprecedented tetraterpenoids featuring a 3,4-seco-rearranged lanostane system fused with a 尾-myrcene lateral chain via a [4 + 2] Diels鈥揂lder cycloaddition, were isolated from the oleoresin of Abies balsamea. Their structures were elucidated by means of extensive 2D NMR, IR, and MS spectroscopy analyses. The absolute configuration of 1 was determined by single-crystal X-ray diffraction. Both compounds exhibited significant cytotoxic activity against cancer cell lines.